ELISA CCAR2 anti-

Quantity :100µL Clone Number: Aliases:CCAR2 antibody; DBC1 antibody; KIAA1967Cell cycle and apoptosis regµLator protein 2 antibody; Cell division cycle and apoptosis regµLator protein 2 antibody; DBIRD complex subunit KIAA1967 antibody; Deleted in breast cancer gene 1 protein antibody; DBC-1 antibody; DBC.1 antibody; NET35 antibody; p30 DBC antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q8N163 Immunogen:SyntheQuantityd peptide derived from internal of KIAA1967. Raised in:Rabbit Reactivity: Tested Applications:ELISA, WB; WB:1:500-1:3000 Background:Core component of the DBIRD complex, a mµLtiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regµLation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity. As part of a histone H3-specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors. Plays a critical role in maintaining genomic stability and cellµLar integrity following UV-induced genotoxic stress. Nagase T., DNA Res. 8:319-327(2001). Hamaguchi M., Proc. Natl. Acad. Sci. U.S.A. 99:13647-13652(2002). Olsen J.V., Cell 127:635-648(2006). Clonality:Polyclonal Isotype:IgG Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:CCAR2 Research Areas:Epigenetics and Nuclear Signaling