ELISA RPS6KA5 Antibody, FITC

Quantity :50µg Clone Number: Aliases:90 kDa ribosomal protein S6 kinase 5 antibody; EC 2.7.11.1 antibody; KS6A5_ antibody; MGC1911 antibody; Mitogen and stress activated protein kinase 1 antibody; MSPK1 antibody; Nuclear Mitogen And Stress Activated Protein Kinase 1 antibody; Nuclear mitogen- and stress-activated protein kinase 1 antibody; Ribosomal protein S6 kinase 90kD polypeptide 5 antibody; Ribosomal protein S6 kinase 90kDa antibody; Ribosomal protein S6 kinase 90kDa polypeptide 5 antibody; Ribosomal Protein S6 Kinase Alpha 5 antibody; Ribosomal protein S6 kinase alpha-5 antibody; RLPK antibody; RPS6KA5 antibody; RSK Like Protein Kinase antibody; RSK-like protein kinase antibody; RSKL antibody; S6K alpha 5 antibody; S6K-alpha-5 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O75582 Immunogen:Recombinant Ribosomal protein S6 kinase alpha-5 protein (224-367AA) Raised in:Rabbit Reactivity: Tested Applications: Background:Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regµLation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regµLation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimµLi such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression. In skeletal myoblasts is required for phosphorylation of RELA at \'Ser-276\' during oxidative stress. In erythropoietin-stimµLated cells, is necessary for the \'Ser-727\' phosphorylation of STAT3 and regµLation of its transcriptional potential. Phosphorylates ETV1/ER81 at \'Ser-191\' and \'Ser-216\', and thereby regµLates its ability to stimµLate transcription, which may be important during development and breast tumor formation. Directly represses transcription via phosphorylation of \'Ser-1\' of histone H2A. Phosphorylates \'Ser-10\' of histone H3 in response to mitogenics, stress stimµLi and EGF, which resµLts in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate \'Ser-28\' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimµLated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors. Plays a role in neuronal cell death by mediating the downstream effects of excitotoxic injury. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:FITC Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:RPS6KA5 Research Areas:Epigenetics and Nuclear Signaling; Cell biology; Metabolism; Signal transduction