ELISA MEIS2 Antibody, Biotin

Quantity :50µg Clone Number: Aliases:Homeobox protein Meis2 antibody; HsT18361 antibody; Meis (mouse) homolog 2 antibody; Meis homeobox 2 antibody; Meis homolog 2 antibody; Meis1 myeloid ecotropic viral integration site 1 homolog 2 (mouse) antibody; Meis1 myeloid ecotropic viral integration site 1 homolog 2 antibody; Meis1 related gene 1 antibody; Meis1 related protein 1 antibody; Meis1-related protein 1 antibody; MEIS2 antibody; MEIS2_ antibody; MGC2820 antibody; MRG1 antibody; TALE homeobox protein Meis2 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O14770 Immunogen:Recombinant Homeobox protein Meis2 protein (377-470AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Involved in transcriptional regµLation. Binds to HOX or PBX proteins to form dimers, or to a DNA-bound dimer of PBX and HOX proteins and thoµght to have a role in stabilization of the homeoprotein-DNA complex. Isoform 3 is required for the activity of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element; MEIS2 is not involved in complex DNA-binding. Probably in complex with PBX1, is involved in transcriptional regµLation by KLF4. Isoform 3 and isoform 4 can bind to a EPHA8 promoter sequence containing the DNA motif 5\'-CGGTCA-3\'; in cooperation with a PBX protein (such as PBX2) is proposed to be involved in the transcriptional activation of EPHA8 in the developing midbrain. May be involved in regµLation of myeloid differentiation. Can bind to the DNA sequence 5\'-TGACAG-3\'in the activator ACT sequence of the D(1A) dopamine receptor (DRD1) promoter and activate DRD1 transcription; isoform 5 cannot activate DRD1 transcription. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:MEIS2 Research Areas:Epigenetics and Nuclear Signaling; Neuroscience