ELISA Lcn2 anti-

Quantity :50µL Clone Number: Aliases:Lcn2 antibody; Neutrophil gelatinase-associated lipocalin antibody; NGAL antibody; Alpha-2-microglobµLin-related protein antibody; Alpha-2U globµLin-related protein antibody; Lipocalin 24p3 antibody; Lipocalin-2 antibody; Siderocalin LCN2 antibody; p25 antibody Product Type:Polyclonal Antibody Immunogen Species:Rattus norvegicus (Rat) UniProt ID:P30152 Immunogen:Recombinant Rat Lcn2 protein (1-198AA) Raised in:Rabbit Reactivity:Rat Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:100-1:500 Background:Iron-trafficking protein involved in mµLtiple processes such as apoptosis, innate immunity and renal development (By similarity). Binds iron throµgh association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellµLar iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellµLar siderophore, iron chelation and iron transfer to the extracellµLar medium, thereby reducing intracellµLar iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellµLar iron concentration without promoting apoptosis, while iron-free form decreases intracellµLar iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resµLting in apoptosis (By similarity). Involved in innate immunity; limits bacterial proliferation by sequestering iron bound to microbial siderophores, such as enterobactin. Can also bind siderophores from M.tubercµLosis (By similarity). Clonality:Polyclonal Isotype:IgG Purification Method:Antigen Affinity Purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:Lcn2 Research Areas:CardiovascµLar