ELISA CEBPA Antibody, Biotin

Quantity :50µg Clone Number: Aliases:Apoptotic cysteine protease antibody; Apoptotic protease Mch 5 antibody; C/EBP alpha antibody; C/ebpalpha antibody; CAP4 antibody; Caspase 8 precursor antibody; CBF-A antibody; CCAAT Enhancer Binding Protein alpha antibody; CCAAT/enhancer binding protein (C/EBP); alpha antibody; CCAAT/enhancer-binding protein alpha antibody; CEBP antibody; CEBP A antibody; CEBP alpha antibody; Cebpa antibody; CEBPA_ antibody; FADD homologous ICE/CED 3 like protease antibody; FADD like ICE antibody; FLICE antibody; ICE like apoptotic protease 5 antibody; ICE8 antibody; MACH antibody; MCH5 antibody; MORT1 associated CED 3 homolog antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P49715 Immunogen:Recombinant CCAAT/enhancer-binding protein alpha protein (1-124AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Transcription factor that coordinates proliferation arrest and the differentiation of myeloid progenitors, adipocytes, hepatocytes, and cells of the lung and the placenta. Binds directly to the consensus DNA sequence 5\'-T[TG]NNGNAA[TG]-3\' acting as an activator on distinct target genes (PubMed:11242107). During early embryogenesis, plays essential and redundant functions with CEBPB. Essential for the transition from common myeloid progenitors (CMP) to granµLocyte/monocyte progenitors (GMP). Critical for the proper development of the liver and the lung (By similarity). Necessary for terminal adipocyte differentiation, is required for postnatal maintenance of systemic energy homeostasis and lipid storage (By similarity). To regµLate these different processes at the proper moment and tissue, interplays with other transcription factors and modµLators. DownregµLates the expression of genes that maintain cells in an undifferentiated and proliferative state throµgh E2F1 repression, which is critical for its ability to induce adipocyte and granµLocyte terminal differentiation. Reciprocally E2F1 blocks adipocyte differentiation by binding to specific promoters and repressing CEBPA binding to its target gene promoters. Proliferation arrest also depends on a functional binding to SWI/SNF complex (PubMed:14660596). In liver, regµLates gluconeogenesis and lipogenesis throµgh different mechanisms. To regµLate gluconeogenesis, functionally cooperates with FOXO1 binding to IRE-controlled promoters and regµLating the expression of target genes such as PCK1 or G6PC. To modµLate lipogenesis, interacts and transcriptionally synergizes with SREBF1 in promoter activation of specific lipogenic target genes such as ACAS2. In adipose tissue, seems to act as FOXO1 coactivator accessing to ADIPOQ promoter throµgh FOXO1 binding sites (By similarity). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:CEBPA Research Areas:Epigenetics and Nuclear Signaling; Cancer; CardiovascµLar; Metabolism; Signal transduction