ELISA CCNC Antibody, Biotin

Quantity :50µg Clone Number: Aliases:ccnc antibody; CCNC_ antibody; CycC antibody; Cyclin C antibody; Cyclin-C antibody; hSRB11 antibody; OTTHUMP00000016897 antibody; SRB11 homolog antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P24863 Immunogen:Recombinant Cyclin-C protein (240-283AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Component of the Mediator complex, a coactivator involved in regµLated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regµLatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regµLatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:CCNC Research Areas:Epigenetics and Nuclear Signaling; Cell biology