ELISA CBL Antibody, HRP

Quantity :50µg Clone Number: Aliases:4732447J05Rik antibody; C CBL antibody; Cas Br M (murine) ecotropic retroviral transforming sequence antibody; Casitas B lineage lymphoma proto oncogene antibody; Casitas B-lineage lymphoma proto-oncogene antibody; CBL 2 antibody; cbl antibody; CBL_ antibody; CBL2 antibody; E3 ubiquitin protein ligase CBL antibody; E3 ubiquitin-protein ligase CBL antibody; Oncogene CBL2 antibody; Proto oncogene c CBL antibody; Proto-oncogene c-CBL antibody; RGD1561386 antibody; RING finger protein 55 antibody; RNF55 antibody; Signal transduction protein CBL antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P22681 Immunogen:Recombinant E3 ubiquitin-protein ligase CBL protein (548-847AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Adapter protein that functions as a negative regµLator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjµgating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, EGFR, CSF1R, EPHA8 and KDR and terminates signaling. Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation. Participates in signal transduction in hematopoietic cells. Plays an important role in the regµLation of osteoblast differentiation and apoptosis. Essential for osteoclastic bone resorption. The \'Tyr-731\' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:HRP Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:CBL Research Areas:Epigenetics and Nuclear Signaling; Cancer; Cell biology; Signal transduction