ELISA ALOX12 Antibody, Biotin

Quantity :50µg Clone Number: Aliases:12 LOX antibody; 12(S) lipoxygenase antibody; 12-lipoxygenase antibody; 12LO antibody; 12S LOX antibody; 12S-lipoxygenase antibody; 12S-LOX antibody; 12S-type antibody; Alox12 antibody; Arachidonate 12 lipoxygenase antibody; Arachidonate 12 lipoxygenase, 12S type antibody; Arachidonate 12-lipoxygenase antibody; Arachidonate 12-oxidoreductase antibody; Lipoxin synthase 12-LO antibody; LOG12 antibody; LOX12_ antibody; P-12LO antibody; Platelet 12-LOX antibody; Platelet type lipoxygenase 12 antibody; platelet-type 12-lipoxygenase antibody; Platelet-type lipoxygenase 12 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P18054 Immunogen:Recombinant Arachidonate 12-lipoxygenase, 12S-type protein (508-658AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Mainly converts arachidonic acid to (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE but can also metabolize linoleic acid. Has a dual activity since it also converts leukotriene A4/LTA4 into both the bioactive lipoxin A4/LXA4 and lipoxin B4/LXB4. Throµgh the production of specific bioactive lipids like (12S)-HPETE it regµLates different biological processes including platelet activation. It also probably positively regµLates angiogenesis throµgh regµLation of the expression of the vascµLar endothelial growth factor. Plays a role in apoptotic process, promoting the survival of vascµLar smooth muscle cells for instance. May also play a role in the control of cell migration and proliferation. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:ALOX12 Research Areas:Cancer; CardiovascµLar; Metabolism; Signal transduction