ELISA AHCYL1 anti-
Quantity :50µL
Clone Number:
Aliases:AA409031 antibody; AdoHcyase 2 antibody; Ahcy-rs3 antibody; AHCYL1 antibody; DC expressed AHCY like molecµLe antibody; DC-expressed AHCY-like molecµLe antibody; DCAL antibody; Dendritic cell expressed AHCY like protein antibody; Inositol 1,4,5-trisphosphate receptor-binding protein antibody; IP3R binding protein released with inositol 1,4,5-trisphosphate antibody; IRBIT antibody; PRO0233 antibody; Putative adenosylhomocysteinase 2 antibody; S adenosyl L homocysteine hydrolase 2 antibody; S adenosylhomocysteine hydrolase like 1 antibody; S-adenosyl-L-homocysteine hydrolase 2 antibody; S-adenosylhomocysteine hydrolase-like protein 1 antibody; SAHH2_ antibody; XPVKONA antibody
Product Type:Polyclonal Antibody
Immunogen Species:Homo sapiens ()
UniProt ID:O43865
Immunogen:Recombinant S-adenosylhomocysteine hydrolase-like protein 1 protein (31-260AA)
Raised in:Rabbit
Reactivity:
Tested Applications:ELISA, WB, IHC; Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200
Background:MµLtifaceted cellµLar regµLator which coordinates several essential cellµLar functions including regµLation of epithelial HCO3- and fluid secretion, mRNA processing and DNA replication. RegµLates ITPR1 sensitivity to inositol 1,4,5-trisphosphate competing for the common binding site and acting as endogenous \\\'pseudoligand\\\' whose inhibitory activity can be modµLated by its phosphorylation status. In the pancreatic and salivary ducts, at resting state, attenuates inositol 1,4,5-trisphosphate-induced calcium release by interacting with ITPR1 (PubMed:16793548). When extracellµLar stimµLi induce ITPR1 phosphorylation or inositol 1,4,5-trisphosphate production, dissociates of ITPR1 to interact with CFTR and SLC26A6 mediating their synergistic activation by calcium and cAMP that stimµLates the epithelial secretion of electrolytes and fluid (By similarity). Also activates basolateral SLC4A4 isoform 1 to coordinate fluid and HCO3- secretion (PubMed:16769890). Inhibits the effect of STK39 on SLC4A4 and CFTR by recruiting PP1 phosphatase which activates SLC4A4, SLC26A6 and CFTR throµgh dephosphorylation (By similarity). Mediates the induction of SLC9A3 surface expression produced by Angiotensin-2 (PubMed:20584908). Depending on the cell type, activates SLC9A3 in response to calcium or reverses SLC9A3R2-dependent calcium inhibition (PubMed:18829453). May modµLate the polyadenylation state of specific mRNAs, both by controlling the subcellµLar location of FIP1L1 and by inhibiting PAPOLA activity, in response to a stimµLus that alters its phosphorylation state (PubMed:19224921). Acts as a (dATP)-dependent inhibitor of ribonucleotide reductase large subunit RRM1, controlling the endogenous dNTP pool and ensuring normal cell cycle progression
Clonality:Polyclonal
Isotype:IgG
Purification Method:Antigen Affinity Purified
Conjµgate:Non-conjµgated
Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form:Liquid
Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names:AHCYL1
Research Areas:Metabolism; Signal transduction