ELISA CD163 Monoclonal anti-

Quantity :50µL Clone Number: Aliases:Scavenger receptor cysteine-rich type 1 protein M130 (Hemoglobin scavenger receptor) (CD antigen CD163) [Cleaved into: Soluble CD163 (sCD163)], CD163, M130 Product Type:Monoclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q86VB7 Immunogen:SyntheQuantityd peptide derived from CD163 Raised in:Mouse Reactivity: Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200 Background:Acute phase-regµLated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and mµLtimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellµLar signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells. Clonality:Monoclonal Isotype:IgG1, Kappa Purification Method:The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. Conjµgate:Non-conjµgated Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:CD163 Research Areas:Immunology