ELISA CDK8 anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Component of the Mediator complex, a coactivator involved in regµLated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regµLatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regµLatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD(C-terminal domain) of the large subunit of RNA polymerase II(RNAp II), which may inhibit the formation of a transcription initiation complex. Phosphorylates CCNH leading to down-regµLation of the TFIIH complex and transcriptional repression. Recruited throµgh interaction with MAmL1 to hyperphosphorylate the intracellµLar domain of NOTCH, leading to its degradation. Immunogen:cyclin-dependent kinase 8 Synonyms: Observed MW:53 kDa Uniprot ID:P49336 Reactivity:, Mouse Tested Application:ELISA, WB, IHC Recommended dilution:WB: 1:500-1:2000; IHC: 1:20-1:200 Gene ID:1024 Research Area:Cell Division and Proliferation, Metabolism