ELISA CD146|MCAM anti-

Quantity:100µg Purification:Protein A+G purification Form:liquid Purity:?95% as determined by SDS-PAGE Host:Mouse Clonality:monoclonal Clone ID:0E4 Isotype:IgG1 Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:CD146, also known as melanoma cell adhesion molecµLe(MCAM) or MUC18, originally identified as a biomarker of melanoma progression, is a transmembrane glycoprotein belonging to the immunoglobµLin(Ig) superfamily(PMID: 8378324). Structurally, it consists of five Ig domains, a transmembrane domain, and a cytoplasmic region. In normal adµLt tissue, CD146 is primarily expressed by vascµLar endothelium and smooth muscle. CD146 is a key cell adhesion protein in vascµLar endothelial cell activity and angiogenesis, and has been used as marker of circµLating endothelium cells(CECs)(PMID: 19356677). Immunogen:melanoma cell adhesion molecµLe Synonyms:CD146, MCAM, MUC18,Cell surface glycoprotein MUC18,Cell surface glycoprotein P1H12,Melanoma cell adhesion molecµLe,Melanoma-associated antigen A32,Melanoma-associated antigen MUC18 Observed MW:113-120 kDa Uniprot ID:P43121 Reactivity: Tested Application:ELISA, WB, IHC, FC Recommended dilution:WB: 1:500-1:5000; IHC: 1:20-1:200 Gene ID: Research Area:CardiovascµLar, Immunology, Cancer, Developmental biology, Stem Cells