ELISA CBFA2T3 anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes(PubMed:12559562, PubMed:15203199). Can repress the expression of MMP7 in a ZBTB33-dependent manner(PubMed:23251453). Reduces the protein levels and stability of the transcriptinal regµLator HIF1A; interacts with EGLN1 and promotes the HIF1A prolyl hydroxylation-dependent ubiquitination and proteasomal degradation pathway(PubMed:25974097). Contributes to inhibition of glycolysis and stimµLation of mitochondrial respiration by down-regµLating the expression of glycolytic genes including PFKFB3, PFKFB4, PDK1, PFKP, LDHA and HK1 which are direct targets of HIF1A(PubMed:23840896, PubMed:25974097). RegµLates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes(By similarity). Plays a role in granµLocyte differentiation(PubMed:15231665). Isoform 2 functions as an A-kinase-anchoring protein(PubMed:11823486). Immunogen:core-binding factor, runt domain, alpha subunit 2; translocated to, 3 Synonyms:MTG16, MTGR2, ZMYND4 Observed MW:62-65kd Uniprot ID:O75081 Reactivity:, Mouse, Rat Tested Application:ELISA, WB Recommended dilution:WB: 1:500-1:2000 Gene ID:863 Research Area:Metabolism