ELISA Angiotensinogen anti-

Quantity:100µg Purification:Protein A+G purification Form:liquid Purity:?95% as determined by SDS-PAGE Host:Mouse Clonality:monoclonal Clone ID:0F2 Isotype:IgG2b Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Angiotensinogen is a precursor of angiotensin II(Ang II), is expressed and syntheQuantityd largely in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. It has a key role in mediating vascµLar constriction and regµLating salt and fluid homeostasis. The resµLting product, angiotensin I, is then cleaved by angiotensin converting enzyme(ACE) to generate the physiologically active enzyme angiotensin II. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubµLar dysgenesis, a severe disorder of renal tubµLar development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease. Immunogen:angiotensinogen(serpin peptidase inhibitor, clade A, member 8) Synonyms:AGT, Ang I Angiotensin 2, Ang II Angiotensin 3, Ang III, Angiotensin I, Angiotensin II, Angiotensin III, Angiotensinogen, ANHU, Des Asp[1] angiotensin II, FLJ92595, FLJ97926, Serpin A8, SERPINA8 Observed MW:53 kDa Uniprot ID:P01019 Reactivity: Tested Application:ELISA, WB, IHC Recommended dilution:WB: 1:500-1:5000; IHC: 1:20-1:200 Gene ID:183 Research Area:CardiovascµLar, Metabolism