ELISA AGAP2 anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:GTPase-activating protein(GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1(GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimµLate PI3 kinase but may protect cells from apoptosis by stimµLating Akt. It also regµLates the adapter protein 1(AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion. Immunogen:ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 Synonyms:AGAP 2, AGAP2, Centaurin gamma 1, CENTG1, Cnt g1, FLJ16430, GGAP2, KIAA0167, PIKE Observed MW:125 kDa Uniprot ID:Q99490 Reactivity:, Mouse, Rat Tested Application:ELISA, WB, IHC, IF Recommended dilution:WB: 1:500-1:5000; IP: 1:200-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200 Gene ID:116986 Research Area:Signal Transduction