ELISA AGO3 anti-

Quantity :50µL Clone Number:4F7 Aliases:Protein argonaute-3UniRµLe annotation, Argonaute RISC catalytic component 3, Eukaryotic translation initiation factor 2C 3UniRµLe annotation, AGO3, EIF2C3 Product Type:Recombinant Antibody Immunogen Species: UniProt ID:Q9H9G7 Immunogen:A syntheQuantityd peptide derived from AGO3 Raised in: Reactivity: Tested Applications:ELISA Background:Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Proposed to be involved in stabilization of small RNA derivates (riRNA) derived from processed RNA polymerase III-transcribed Alu repeats containing a DR2 retinoic acid response element (RARE) in stem cells and in the subsequent riRNA-dependent degradation of a subset of RNA polymerase II-transcribed coding mRNAs by recruiting a mRNA decapping complex involving EDC4. Possesses RNA slicer activity but only on select RNAs bearing 5'- and 3'-flanking sequences to the region of guide-target complementarity (PubMed:29040713). Clonality:Monoclonal Isotype:Rabbit IgG Purification Method:Affinity-chromatography Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:AGO3 Research Areas:Epigenetics and Nuclear Signaling