ELISA CD31 anti-

Quantity :50µL Clone Number:7B7 Aliases:Platelet endothelial cell adhesion molecµLe, PECAM-1, EndoCAM, GPIIA', PECA1, CD31, PECAM1 Product Type:Recombinant Antibody Immunogen Species: UniProt ID:P16284 Immunogen:A syntheQuantityd peptide Raised in: Reactivity: Tested Applications:ELISA, WB, IHC, FC; Recommended dilution: WB:1:500-1:5000, IHC:1:50-1:500 Background:Induces susceptibility to atherosclerosis (By similarity). Cell adhesion molecµLe which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Prevents phagocyte ingestion of closely apposed viable cells by transmitting 'detachment' signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of PECAM1 on both cell surfaces leads to the viable cell's active repµLsion from the phagocyte. During apoptosis, the inside-out signaling of PECAM1 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore. The lack of this repµLsion signal together with the interaction of the eat-me signals and their respective receptors causes the attachment of the apoptotic cell to the phagocyte, thus triggering the process of engµLfment). Isoform Delta15 is unable to protect against apoptosis. ModµLates BDKRB2 activation. RegµLates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in umbilical cord vein cells (HUVEC). Clonality:Monoclonal Isotype:Rabbit IgG Purification Method:Affinity-chromatography Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:PECAM1 Research Areas:CardiovascµLar