ELISA ADO anti-

Quantity :50µL Clone Number: Aliases:2 aminoethanethiol dioxygenase antibody; 2-aminoethanethiol dioxygenase antibody; ADO 2 aminoethanethiol (cysteamine) dioxygenase antibody; ADO antibody; AEDO_ antibody; C10orf22 antibody; Chromosome 10 open reasing frame 22 antibody; cysteamine (2-aminoethanethiol) dioxygenase (ADO) antibody; Cysteamine dioxygenase antibody; DKFZp564C046 antibody; FLJ14547 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q96SZ5 Immunogen:Synthetic peptide of ADO Raised in:Rabbit Reactivity:, Mouse Tested Applications:ELISA, WB, IHC; ELISA:1:1000-1:10000, WB:1:1000-1:5000, IHC:1:25-1:100 Background: thiol dioxygenases include cysteine dioxygenase (CDO, MIM 603943) and cysteamine (2-aminoethanethiol) dioxygenase (ADO, EC 1.13.11.19). CDO adds 2 oxygen atoms to free cysteine, whereas ADO adds 2 oxygen atoms to free cysteamine to form hypotaurine. Mouse Ado has strong and specific dioxygenase activity in vitro towards cysteamine but not cysteine. Recombinant Ado was shown to bind iron. Overexpression of Ado in HepG2/C3A cells increased the production of hypotaurine from cysteamine. Similar resµLts were found with ADO. When endogenous expression of ADO was reduced by RNA-mediated interference, hypotaurine production decreased. The demonstration of high levels of ADO in brain challenges the previous assumption that most of the taurine in the brain is a consequence of CDO activity. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen affinity purification Conjµgate:Non-conjµgated Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:ADO Research Areas:Metabolism;Signal transduction