ELISA CCND2 (Ab-280) anti-

Quantity :100µL Clone Number: Aliases:CCND 2 antibody; ccnd2 antibody; CCND2_ antibody; CyclinD2 antibody; G1/S specific cyclin D2 antibody; G1/S-specific cyclin-D2 antibody; KIAK0002 antibody; MGC102758 antibody; MPPH3 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P30279 Immunogen:SyntheQuantityd non-phosphopeptide derived from Cyclin D2 around the phosphorylation site of threonine 280 (A-S-T(p)-P-T). Raised in:Rabbit Reactivity:, Mouse Tested Applications:ELISA, WB; WB:1:500-1:3000 Background:RegµLatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regµLates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression throµgh the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex By similarity. Xiong Y., Genomics 13:575-584(1992). Palmero I., Oncogene 8:1049-1054(1993). Kalnine N., Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases. Clonality:Polyclonal Isotype:IgG Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:CCND2 Research Areas:Epigenetics and Nuclear Signaling;Cancer;Cell biology