ELISA BRCA1 (Ab-1524) anti-

Quantity :100µL Clone Number: Aliases:BRCA 1 antibody; BRCA1 antibody; BRCA1 DNA repair associated antibody; BRCA1/BRCA2 containing complex subunit 1 antibody; BRCA1/BRCA2-containing complex; subunit 1 antibody; BRCA1_ antibody; BRCAI antibody; BRCC 1 antibody; BRCC1 antibody; Breast and ovarian cancer susceptibility protein 1 antibody; Breast Cancer 1 antibody; Breast Cancer 1 Early Onset antibody; Breast cancer type 1 susceptibility protein antibody; BROVCA1 antibody; FANCS antibody; IRIS antibody; PNCA4 antibody; PPP1R53 antibody; Protein phosphatase 1 regµLatory subunit 53 antibody; PSCP antibody; RING finger protein 53 antibody; RNF53 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P38398 Immunogen:Peptide sequence around aa.1522~1526 (Y-P-S-Q-E) derived from BRCA1. Raised in:Rabbit Reactivity: Tested Applications:ELISA, WB, IF; WB:1:500-1:1000, IF:1:100-1:200 Background:The BRCA1-BARD1 heterodimer coordinates a diverse range of cellµLar pathways such as DNA damage repair, ubiquitination and transcriptional regµLation to maintain genomic stability. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Plays a central role in DNA repair by facilitating cellµLar response to DNA repair. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regµLation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regµLator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation Lin SY, et al. (2004) Proc Natl Acad Sci U S A, 101(17): 6484-6489 Zhang J, et al. (2004) Mol Cell Biol; 24(2): 708-718 Beger C, et al. (2001) Proc Natl Acad Sci U S A; 98(1): 130-135 Gardner K, et al. (2001) Breast Cancer Res; 3(1): 11-13 Zheng L, et al. (2001) Proc Natl Acad Sci U S A; 98(17): 9587-9592 Clonality:Polyclonal Isotype:IgG Purification Method:Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjµgates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. Conjµgate:Non-conjµgated Buffer:Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:BRCA1 Research Areas:Epigenetics and Nuclear Signaling;Cancer;Cell biology