ELISA BABAM2 Antibody, HRP

Quantity :50µg Clone Number: Aliases:6030405P19Rik antibody; AI429776 antibody; B830038C02Rik antibody; Brain and reproductive organ expressed (TNFRSF1A modµLator) antibody; brain and reproductive organ expressed protein antibody; Brain and reproductive organ-expressed protein antibody; BRCA1 A complex subunit BRE antibody; BRCA1-A complex subunit BRE antibody; BRCA1/BRCA2 containing complex subunit 4 antibody; BRCA1/BRCA2 containing complex subunit 45 antibody; BRCA1/BRCA2-containing complex subunit 45 antibody; BRCC4 antibody; BRCC45 antibody; bre antibody; BRE_ antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9NXR7 Immunogen:Recombinant BRISC and BRCA1-A complex member 2 protein (94-383AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Component of the BRCA1-A complex, a complex that specifically recognizes \'Lys-63\'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes \'Lys-63\'-linked ubiquitin on histones H2A and H2AX (PubMed:17525341, PubMed:19261746, PubMed:19261749, PubMed:19261748). In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modµLating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer (PubMed:21282113, PubMed:19261748). Component of the BRISC complex, a mµLtiprotein complex that specifically cleaves \'Lys-63\'-linked ubiquitin in various substrates (PubMed:19214193, PubMed:24075985, PubMed:25283148, PubMed:26195665). Within the BRISC complex, acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity (PubMed:21282113). The BRISC complex is required for normal mitotic spindle assembly and microtubµLe attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). The BRISC complex plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression (PubMed:24075985). Down-regµLates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). May play a role in homeostasis or cellµLar differentiation in cells of neural, epithelial and germLine origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway. May regµLate TNF-alpha signaling throµgh its interactions with TNFRSF1A; however these effects may be indirect (PubMed:15465831). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:HRP Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:BABAM2 Research Areas:Epigenetics and Nuclear Signaling; Cancer; Cell biology