ELISA CATSPER2 Antibody, HRP

Quantity :50µg Clone Number: Aliases:CATSPER2 antibody; Cation channel sperm-associated protein 2 antibody; CatSper2 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q96P56 Immunogen:Recombinant Cation channel sperm-associated protein 2 protein (5-112AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successfµL fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellµLar progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellµLar pH. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:HRP Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:CATSPER2 Research Areas:Others