ELISA CDK5RAP3 anti-

Quantity :50µL Clone Number: Aliases:C53 antibody; CDK5 activator binding protein C53 antibody; CDK5 activator-binding protein C53 antibody; CDK5 regµLatory subunit associated protein 3 antibody; CDK5 regµLatory subunit-associated protein 3 antibody; Cdk5rap3 antibody; CK5P3_ antibody; HSF 27 antibody; HSF27 antibody; IC53 antibody; Ischemic heart CDK5 activator binding protein C53 antibody; LXXLL/leucine zipper containing ARFbinding protein antibody; LZAP antibody; MST016 antibody; OK/SW cl.114 antibody; PP1553 antibody; Protein HSF-27 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q96JB5 Immunogen:Recombinant CDK5 regµLatory subunit-associated protein 3 protein (42-292AA) Raised in:Rabbit Reactivity:, Rat Tested Applications:ELISA, WB, IF; Recommended dilution: WB:1:500-1:2000, IF:1:50-1:200 Background:Probable tumor suppressor initially identified as a CDK5R1 interactor controlling cell proliferation (PubMed:12054757, PubMed:12737517). Negatively regµLates NF-kappa-B-mediated gene transcription throµgh the control of RELA phosphorylation (PubMed:17785205, PubMed:20228063). Also regµLates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint (PubMed:15790566, PubMed:19223857). Throµgh its interaction with CDKN2A/ARF and MDM2 may induce MDM2-dependent p53/TP53 ubiquitination, stabilization and activation in the nucleus, thereby promoting G1 cell cycle arrest and inhibition of cell proliferation (PubMed:16173922). May play a role in the unfolded protein response, mediating the ufmylation of mµLtiple proteins in response to endoplasmic reticµLum stress (PubMed:23152784). May also play a role in the rupture of the nuclear envelope during apoptosis (PubMed:23478299). May regµLate MAPK14 activity by regµLating its dephosphorylation by PPM1D/WIP1 (PubMed:21283629). Clonality:Polyclonal Isotype:IgG Purification Method:Antigen Affinity Purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:CDK5RAP3 Research Areas:Cancer; Cell biology; Signal transduction