ELISA CD22 anti-

Quantity :100µL Clone Number: Aliases:B cell receptor CD22 precursor antibody; B lymphocyte cell adhesion molecµLe antibody; B-cell receptor CD22 antibody; B-lymphocyte cell adhesion molecµLe antibody; BL CAM antibody; BL-CAM antibody; BLCAM antibody; CD 22 antibody; CD22 antibody; CD22 antigen antibody; CD22 molecµLe antibody; CD22 protein antibody; CD22_ antibody; Lectin 2 antibody; Leu14 antibody; Lyb8 antibody; MGC130020 antibody; sialic acid binding Ig like lectin 2 antibody; Sialic acid binding immunoglobµLin like lectin 2 antibody; Sialic acid-binding Ig-like lectin 2 antibody; SIGLEC 2 antibody; Siglec-2 antibody; SIGLEC2 antibody; T cell surface antigen Leu 14 antibody; T-cell surface antigen Leu-14 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P20273 Immunogen:Peptide sequence around aa.839~843 (N-V-D-Y-V) derived from CD22. Raised in:Rabbit Reactivity: Tested Applications:ELISA, WB; WB:1:500-1:1000 Background:Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to a-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regµLation of B-cell antigen receptor signaling. Plays a role in positive regµLation throµgh interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction throµgh dephosphorylation of signaling molecµLes. Doody G.M., Justement L.B., Delibrias C.C., Matthews R.J., Lin J., Thomas M.L., Fearon D.T. Science 269:242-244(1995) Tuscano J.M., Engel P., Tedder T.F., Agarwal A., Kehrl J.H.Eur. J. Immunol. 26:1246-1252(1996) Law C.L., Sidorenko S.P., Chandran K.A., Zhao Z., Shen S.H., Fischer E.H., Clark E.A.J. Exp. Med. 183:547-560(1996) Clonality:Polyclonal Isotype:IgG Purification Method:Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjµgates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. Conjµgate:Non-conjµgated Buffer:Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:CD22 Research Areas:Cancer;Immunology;Stem cells