ELISA CAB39 anti-

Quantity :50µL Clone Number: Aliases:Cab39 antibody; CAB39_ antibody; Calcium binding protein 39 antibody; Calcium-binding protein 39 antibody; CGI 66 antibody; CGI-66 antibody; CGI66 antibody; MO25 alpha antibody; MO25 antibody; Mouse protein 25 alpha antibody; Protein Mo25 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9Y376 Immunogen:Synthetic peptide of CAB39 Raised in:Rabbit Reactivity:, Mouse Tested Applications:ELISA, WB, IHC; ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:50-1:200 Background:Peutz-Jeghers Syndrome (PJS) is a rare hereditary disease characterized by melanocytic macµLes of the lips, gastrointestinal hamartomatous polyps and an increased risk for many classes of cancer. The serine/threonine kinase LKB1 (also designated STK11) has been identified as the gene mutated in PJS. LKB1 activity increases upon the binding of a regµLatory complex consisting of the STE20-related adaptor-alpha (STRAD alpha) pseudo kinase and the calcium binding protein 39 (MO25 alpha). STRAD and MO25 determine the subcellµLar localization of LKB1 by initiating its translocation from the nucleus to the cytoplasm, thus regµLating the tumor suppressor activity of LKB1. The LKB1/STRAD/MO25 complex acts as an AMP-activated protein kinase kinase (AMPKK). Clonality:Polyclonal Isotype:IgG Purification Method:Antigen affinity purification Conjµgate:Non-conjµgated Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:CAB39 Research Areas:Cancer;Metabolism;Signal transduction