ELISA ARHGEF1 anti-

Quantity :100µL Clone Number: Aliases:115 kD protein antibody; 115 kDa guanine nucleotide exchange factor antibody; ARHG1_ antibody; ARHGEF 1 antibody; ARHGEF1 antibody; GEF 1 antibody; GEF1 antibody; LBCL 2 antibody; LBCL2 antibody; LSC antibody; Lsc homolog antibody; p115 RhoGEF antibody; p115-RhoGEF antibody; p115RhoGEF antibody; Rho guanine nucleotide exchange factor (GEF) 1 antibody; Rho guanine nucleotide exchange factor 1 antibody; Sub1.5 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q92888 Immunogen:SyntheQuantityd peptide derived from internal of ARHGEF1. Raised in:Rabbit Reactivity: Tested Applications:ELISA, WB; WB:1:500-1:3000 Background:Seems to play a role in the regµLation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimµLates the RhoGEF activity throµgh interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation. Farmer A., Submitted (MAY-2003). Wedegaertner P.B., J. Biol. Chem. 275:14992-14999(2000). Han D.K., Sci. Signal. 2:RA46-RA46(2009). Clonality:Polyclonal Isotype:IgG Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:ARHGEF1 Research Areas:Signal transduction