ELISA BRAP anti-

Quantity :50µg Clone Number: Aliases:BRAP antibody; RNF52BRCA1-associated protein antibody; EC 2.3.2.27 antibody; BRAP2 antibody; Impedes mitogenic signal propagation antibody; IMP antibody; RING finger protein 52 antibody; RING-type E3 ubiquitin transferase BRAP2 antibody; Renal carcinoma antigen NY-REN-63 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q7Z569 Immunogen:Recombinant BRCA1-associated protein (13-124AA) Raised in:Rabbit Reactivity:, Rat Tested Applications:ELISA, WB, IHC, IF; Recommended dilution: WB:1:500-1:5000, IHC:1:200-1:500, IF:1:50-1:200 Background:Negatively regµLates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resµLting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regµLating nuclear transport. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:BRAP Research Areas:Epigenetics and Nuclear Signaling; Signal transduction