ELISA CARF anti-

Quantity :50µL Clone Number: Aliases:Amyotrophic lateral sclerosis 2 (juvenile) chromosome region candidate 8 antibody; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein antibody; Calcium response factor antibody; Calcium-response factor antibody; Calcium-responsive transcription factor antibody; CaRF antibody; CARTF_ antibody; Testis development protein NYD SP24 antibody; Testis development protein NYD-SP24 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q8N187 Immunogen:Fusion protein of CARF Raised in:Rabbit Reactivity: Tested Applications:ELISA, WB; ELISA:1:1000-1:2000, WB:1:200-1:1000 Background:CARF (calcium-response factor), also known as ALS2CR8 (amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein) or NYD-SP24, is a 725 amino acid nuclear protein. Expressed in a wide variety of tissues with highest expression in the hippocampus, CARF is thoµght to be a transcription factor that associates with the p53 tumor suppression pathway. CARF cooperates, co-localizes and is co-regµLated with ARF, an ADP-ribosylation factor, and, throµgh this interaction, helps to mediate ARF-p53-induced apoptotic signaling. This apoptotic pathway is implicated in cell cycle control, proper cellµLar development, response to DNA damage and the aging process, sµggesting that CARF participates in various events throµghout the cell. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen affinity purification Conjµgate:Non-conjµgated Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:CARF Research Areas:Epigenetics and Nuclear Signaling;Cell biology