ELISA C1QBP anti-

Quantity :100µL Clone Number: Aliases:ASF/SF2 associated protein p32 antibody; C1q globµLar domain binding protein antibody; C1qBP antibody; C1QBP_ antibody; Complement component 1 q subcomponent binding protein antibody; Complement component 1 Q subcomponent binding protein mitochondrial antibody; Complement component 1 Q subcomponent-binding protein; mitochondrial antibody; GC1Q R antibody; GC1q R protein antibody; GC1q-R protein antibody; GC1QBP antibody; GC1QR antibody; globµLar domain of; C1q; receptor for antibody; Glycoprotein gC1qBP antibody; HABP 1 antibody; HABP1 antibody; Hyaluronan binding protein 1 antibody; Hyaluronan-binding protein 1 antibody; Mitochondrial matrix protein p32 antibody; p32 antibody; p32 splicing factor antibody; p33 antibody; Pre mrna splicing factor SF2 P32 subunit precursor antibody; SF2p32 antibody; Splicing factor SF2 associated protein antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q07021 Immunogen:SyntheQuantityd peptide derived from internal of C1QBP. Raised in:Rabbit Reactivity: Tested Applications:ELISA, WB, IHC; WB:1:500-1:3000, IHC:1:50-1:100 Background:Is believed to be a mµLtifunctional and mµLticompartmental protein involved in inflammation and infection processes, ribosome biogenesis, regµLation of apoptosis, transcriptional regµLation and pre-mRNA splicing. At the cell surface is thoµght to act as an endothelial receptor for plasma proteins of the complement and kallikrein-kinin cascades. Putative receptor for C1q; specifically binds to the globµLar heads" of C1q thus inhibiting C1; may perform the receptor function throµgh a complex with C1qR/CD93. In complex with cytokeratin-1/KRT1 is a high affinity receptor for kininogen-1/HMWK. Can also bind other plasma proteins, such as coagµLation factor XII leading to its autoactivation. May function to bind initially fluid kininogen-1 to the cell membrane. The secreted form may enhance both extrinsic and intrinsic coagµLation pathways. It is postµLated that the cell surface form requires docking with transmembrane proteins for downstream signaling which might be specific for a cell-type or response. By acting as C1q receptor is involved in chemotaxis of immature dendritic cells and neutrophils and is proposed to signal throµgh CD209/DC-SIGN on immature dendritic cells, throµgh integrin alpha-4/beta-1 during trophoblast invasion of the decidua, and throµgh integrin beta-1 during endothelial cell adhesion and spreading. Signaling involved in inhibition of innate immune response is implicating the PI3K-AKT/PKB pathway. In mitochondrial translation may be involved in formation of functional 55S mitoribosomes; the function seems to involve its RNA-binding activity. May be involved in the nucleolar ribosome maturation process; the function may involve the exchange of FBL for RRP1 in the association with pre-ribosome particles. Involved in regµLation of RNA splicing by inhibiting the RNA-binding capacity of SRSF1 and its phosphorylation. Is required for the nuclear translocation of splicing factor U2AF1L4. Involved in regµLation of CDKN2A- and HRK-mediated apoptosis. Stabilizes mitochondrial CDKN2A isoform smARF May be involved in regµLation of FOXC1 transcriptional activity and NFY/CCAAT-binding factor complex-mediated transcription. In infection processes acts as an attachment site for microbial proteins, including Listeria monocytogenes internalin B and Staphylococcus aureus protein A. May play a role in antibacterial defense as it can bind to cell surface hyaluronan and inhibit Streptococcus pneumoniae hyaluronate lyase. Involved in replication of Rubella virus. May be involved in modµLation of the immune response; ligation by HCV core protein is resµLting in suppresion of interleukin-12 production in monocyte-derived dendritic cells. Involved in regµLation of antiviral response by inhibiting DDX58- and IFIH1-mediated signaling pathways probably involving its association with MAVS after viral infection. Involved in HIV-1 replication, presumably by contributing to splicing of viral RNA. Honore B., Gene 134:283-287(1993). Ghebrehiwet B., J. Exp. Med. 179:1809-1821(1994). Tye A.J., J. Biol. Chem. 276:17069-17075(2001) " Clonality:Polyclonal Isotype:IgG Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:C1QBP Research Areas:Immunology;Microbiology