ELISA CD31 Monoclonal anti-

Quantity :50µL Clone Number:9E6E12 Aliases:Platelet endothelial cell adhesion molecµLe, PECAM-1, EndoCAM, GPIIA', PECA1, CD31, PECAM1 Product Type:Monoclonal Antibody Immunogen Species: UniProt ID:P16284 Immunogen:Recombinant CD31 protein (28-315AA) Raised in:Mouse Reactivity: Tested Applications:ELISA, WB, IHC, IF, FC; Recommended dilution: WB:1:500-1:5000, IHC:1:50-1:500, IF:1:50-1:200 Background:Cell adhesion molecµLe which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions (PubMed:19342684, PubMed:17580308). Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes (PubMed:19342684). Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils (PubMed:17580308). Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal (PubMed:12110892). Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells; PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes (PubMed:12110892). ModµLates bradykinin receptor BDKRB2 activation (PubMed:18672896). RegµLates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells (PubMed:18672896). Induces susceptibility to atherosclerosis (By similarity). Clonality:Monoclonal Isotype:IgG2a Purification Method:>95%, Protein G purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:CD31 Research Areas:Cancer; CardiovascµLar; Immunology; Signal transduction; Stem cells