ELISA COPS8 anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Component of the COP9 signalosome complex(CSN), a complex involved in various cellµLar and developmental processes. The CSN complex is an essential regµLator of the ubiquitin(Ubl) conjµgation pathway by mediating the deneddylation of the cµLlin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Immunogen:COP9 constitutive photomorphogenic homolog subunit 8(Arabidopsis) Synonyms:COP9, COP9 homolog, COPS8, CSN8, hCOP9, SGN8, Signalosome subunit 8 Observed MW:23 kDa Uniprot ID:Q99627 Reactivity:, Mouse, Rat Tested Application:ELISA, WB, IHC Recommended dilution:WB: 1:200-1:2000; IHC: 1:20-1:200 Gene ID:10920 Research Area:stem cells, immunology, Developmental biology, Signal Transduction, Cell Division and Proliferation