ELISA COPS7B Antibody, HRP

Quantity :50µg Clone Number: Aliases:COP9 Complex Homolog Subunit 7b antibody; COP9 Constitutive Photomorphogenic Homolog Subunit 7b antibody; COP9 Signalasome Subunit 7b antibody; COP9 signalosome complex subunit 7b antibody; COPS7B antibody; CSN7B_ antibody; JAB1 Containing Signalosome Subunit 7b antibody; JAB1-containing signalosome subunit 7b antibody; SGN7b antibody; Signalosome subunit 7b antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9H9Q2 Immunogen:Recombinant COP9 signalosome complex subunit 7b protein (1-157AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Component of the COP9 signalosome complex (CSN), a complex involved in various cellµLar and developmental processes. The CSN complex is an essential regµLator of the ubiquitin (Ubl) conjµgation pathway by mediating the deneddylation of the cµLlin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:HRP Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:COPS7B Research Areas:Neuroscience; Signal transduction